Control of vascular tone by purines and pyrimidines

Degradation of purines and pyrimidines by microorganisms.

[This corrects the article on p. 403 in vol. 40.].

Endothelium-derived vasoconstriction by purines and pyrimidines.

The article by Tölle et al1 claims to show for the first time that adenosine 5 -tetraphosphate (AP4) is released on mechanical stimulation from human microvascular endothelial cells in the perfused rat kidney and, further, that AP4 is the most potent mediator of vascular smooth muscle constriction via P2X1 receptors or, indeed, via noradrenaline. It is well established that ATP and UTP released...

Nucleotide Metabolism – Purines and Pyrimidines

Nucleotide metabolism results in the synthesis of the four nucleotides that form DNA. These are further divided in two categories: purines and pyrimidines. Their construction and degradation takes place in a progression of single steps, while different enzymes and cofactors are involved in the process. Beside degradation, there is also a form of reprocessing purine and pyrimidine nucleotides, d...

Receptors for purines and pyrimidines.

Nucleotide Metabolism – Purines and Pyrimidines

Nucleotide metabolism results in the synthesis of the four nucleotides that form DNA. These are further divided in two categories: purines and pyrimidines. Their construction and degradation takes place in a progression of single steps, while different enzymes and cofactors are involved in the process. Beside degradation, there is also a form of reprocessing purine and pyrimidine nucleotides, d...